期刊
SYNTHESIS-STUTTGART
卷 50, 期 1, 页码 139-145出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1590896
关键词
catalyst-free; stereoselectivity; nitrogen and phosphorus heterocycles; polycycles; intramolecular cycloaddition
A concise, atom-economic, and highly regio/stereoselective synthetic strategy was developed for the construction of phosphorus- and nitrogen-fused polycyclic skeleton derivatives. The one-pot, two-step, catalyst-free domino condensation/intramolecular cycloaddition reaction of various substituted 2-(vinylphosphoryloxy)benzaldehydes with pyrazolidin-3-one took place at room temperature. Three new bonds (C-C, 2 x C-N) and two new nitrogen and phosphorus heterocycles were simultaneously constructed. The reaction is particularly attractive due to features such as low cost, mild conditions, atom economy, high stereoselectivity, and potential biological activity of the product.
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