期刊
SYNTHESIS-STUTTGART
卷 49, 期 17, 页码 4065-4081出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1588454
关键词
pyrroles; acylacetylenes; enaminones; intramolecular cyclization; pyrrolo[1,2-a]pyrazines
资金
- Russian Federation (programs for the support of leading scientific schools) [NSh-7145.2016.3]
A concise transition-metal-free strategy for the synthesis of pyrrolo[1,2-a] pyrazines with enone substituents has been developed. It includes the following key steps: (a) cross-coupling of pyrroles with acyl(bromo) acetylenes in solid alumina at room temperature to give 2(acylethynyl)pyrroles; (b) addition of propargylamine to the above acetylenes to form the corresponding N-propargylenaminones; and (c) chemo- and stereoselective base-catalyzed (Cs2CO3/DMSO) intramolecular cyclization of the synthesized propargylic derivatives to form (acylmethylidene)pyrrolo[1,2-a]pyrazines of Z-configuration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据