期刊
ADVANCES IN PHYSIOLOGY EDUCATION
卷 41, 期 4, 页码 578-593出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/advan.00061.2017
关键词
sympathetic; parasympathetic; hypertension; immune system; cytokines
资金
- National Heart, Lung, and Blood Institute Grants [HL-14388, HL-07121]
The autonomic nervous system is a powerful regulator of circulatory adjustments to acute hemodynamic stresses. Here we focus on new concepts that emphasize the chronic influence of the sympathetic and parasympathetic systems on cardiovascular pathology. The autonomic neurohumoral system can dramatically influence morbidity and mortality from cardiovascular disease through newly discovered influences on the innate and adaptive immune systems. Specifically, the end-organ damage in heart failure or hypertension may be worsened or alleviated by pro- or anti-inflammatory pathways of the immune system, respectively, that are activated through neurohumoral transmitters. These concepts provide a major new perspective on potentially life-saving therapeutic interventions in the deadliest of diseases.
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