Organocatalytic Asymmetric Transformations of 3-Substituted 3-Hydroxyisoindolinones

This Account provides an overview of our group's research in the field of asymmetric organocatalytic transformations generating chiral isoindolinone cores. We describe the synthesis of 3-substituted 3-hydroxyisoindolinones as starting materials for these transformations, comprising a wide range of functional groups, as well as their use in asymmetric transformations. We also discuss our efforts in the application of the developed methodology in the synthesis of a known HIV-1 inhibitor. 1 Introduction 2 Synthesis of Isoindolinone Alcohols Comprising Functional Groups 3 Asymmetric Organocatalytic Transformations of Isoindolinone Alcohols 4 Conclusion