4.4 Article

Thieme Chemistry Journals Awardees - Where Are They Now? Ribosylation of an Acid-Labile Glycosyl Acceptor as a Potential Key Step for the Synthesis of Nucleoside Antibiotics

期刊

SYNLETT
卷 29, 期 4, 页码 440-446

出版社

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1591517

关键词

natural products; antibiotics; nucleosides; glycosylation; ribosylation; pentenyl glycosides

资金

  1. Deutsche Forschungsgemeinschaft (DFG) [SFB 803, DU 1095/5-1]
  2. Fonds der Chemischen Industrie (FCI, Sachkostenzuschuss)
  3. Konrad-Adenauer-Stiftung
  4. FCI

向作者/读者索取更多资源

Naturally occurring nucleoside antibiotics (e.g., muraymycins and caprazamycins) represent attractive lead structures for the development of urgently needed novel antibacterial agents. One major challenge in the total synthesis of muraymycins, caprazamycins, and their analogues is the efficient construction of the densely functionalized aminoribosylated uridine-derived core unit. In order to avoid tedious protecting-group manipulations, we have aimed to conduct the aminoribosylation step with an acid-labile glycosyl acceptor. Therefore, different glycosylation approaches have been studied, with pentenyl glycosides giving the best results.

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