期刊
SYNLETT
卷 29, 期 5, 页码 650-654出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1589143
关键词
boron; cross-coupling; green chemistry; palladium; solvents
资金
- University of Strathclyde
- Merck KGaA
The Suzuki-Miyaura (SM) cross-coupling is the most broadly utilized Pd-catalyzed C-C bond-forming reaction in the chemical industry. A large proportion of SM couplings employ dipolar aprotic solvents; however, current sustainability initiatives and increasingly stringent regulations advocate the use of alternatives that exhibit more desirable properties. Here we describe the scope and utility of the bio-derived solvent Cyrene in SM cross-couplings and evaluate its suitability as a reaction medium for this benchmark transformation from discovery to gram scale.
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