期刊
CURRENT EYE RESEARCH
卷 42, 期 12, 页码 1614-1619出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/02713683.2017.1359846
关键词
Atropine; children; myopia; optic disc parameters; retinal fiber layer thickness
资金
- Taipei Tzu Chi Hospital
- Buddhist Tzu Chi Medical Foundation [TCRD-TPE-100-31]
Purpose: To characterize optic disc parameters, retinal nerve fiber layer thickness (RNFLT), and the intraocular pressure (IOP) of myopic children under continual topical 0.25% atropine treatment. Methods: From October 1, 2010 to September 31, 2011, 67 eyes of 35 myopic children were recruited. The children were treated with 0.25% atropine nightly for myopia control. Visual acuity, refraction, IOP, axial length (AL, IOL Master), RNFLT, and optic disc parameters (Stratus OCT) were measured at enrollment and every 2 months. All patients had at least 1 year of follow-up. Results: Enrolled children had a mean age of 10.3 +/- 2.4 years (5-15 years). Of the 67 studied eyes, the mean spherical equivalent (SE) was -2.60 +/- 1.58 diopters (D) (-6.75--0.5 D). Under the treatment of 0.25% atropine, myopia increased by 0.53 +/- 0.10D per year (P < 0.0001), and AL elongated by 0.245 +/- 0.042 mm per year (P < 0.0001). No significant change was noted in the IOP and optic nerve parameters including peripapillary RNFLT, areas of optic disc, cup and rim, or cup/disc ratio over the follow-up period during atropine treatment (P > 0.05). Conclusions: 0.25% Atropine treatment for myopia control did not significantly affect the IOP, optic nerve parameters, and RNFLT in children over a mean of 15.2 +/- 2.4 months treatment and follow-up. 0.25% Atropine is a relatively safe option for myopia control.
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