期刊
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
卷 31, 期 4, 页码 278-286出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WAD.0000000000000208
关键词
machine learning; magnetic resonance imaging; semantics; hippocampus; resting-state
资金
- Italian Ministry of Health [42/RF-2010-2321718]
- European Union Seventh Framework Programme (FP7) [601055]
- EPSRC [EP/M006328/1]
Background: Understanding whether the cognitive profile of a patient indicates mild cognitive impairment (MCI) or performance levels within normality is often a clinical challenge. The use of resting-state functional magnetic resonance imaging (RS-fMRI) and machine learning may represent valid aids in clinical settings for the identification of MCI patients. Methods: Machine-learning models were computed to test the classificatory accuracy of cognitive, volumetric [structural magnetic resonance imaging (sMRI)] and blood oxygen level dependentconnectivity (extracted from RS-fMRI) features, in single-modality and mixed classifiers. Results: The best and most significant classifier was the RS-fMRI + Cognitive mixed classifier (94% accuracy), whereas the worst performing was the sMRI classifier (similar to 80%). The mixed global (sMRI+RS-fMRI+Cognitive) had a slightly lower accuracy (similar to 90%), although not statistically different from the mixed RSfMRI+Cognitive classifier. The most important cognitive features were indices of declarative memory and semantic processing. The crucial volumetric feature was the hippocampus. The RS-fMRI features selected by the algorithms were heavily based on the connectivity of mediotemporal, left temporal, and other neocortical regions. Conclusion: Feature selection was profoundly driven by statistical independence. Some features showed no between-group differences, or showed a trend in either direction. This indicates that clinically relevant brain alterations typical of MCI might be subtle and not inferable from group analysis.
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