期刊
CELL CYCLE
卷 16, 期 22, 页码 2204-2211出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2017.1346754
关键词
CircRNAs; circRNA-miRNA-mRNA; expression profile; liver cancer
类别
资金
- National Natural Science Foundation of China [81602594, 81472662]
- Foundation of Jilin Province Education Department [2016453]
- Innovation fund of Jilin University [JCKY-QKJC25]
- Graduate Innovation fund of Jilin University [2016039]
Liver cancer is the sixth most prevalent cancer, and the third most frequent cause of cancer-related deaths. Circular RNAs (circRNAs), a kind of special endogenous ncRNAs, have been coming back to the forefront of cancer genomics research. In this study, we used a systems biology approach to construct and analyze the circRNA molecular regulatory networks in the context of liver cancer. We detected a total of 127 differentially expressed circRNAs and 3,235 differentially expressed mRNAs. We selected the top-5 upregulated circRNAs to construct a circRNA-miRNA-mRNA network. We enriched the pathways and gene ontology items and determined their participation in cancer-related pathways such as p53 signaling pathway and pathways involved in angiogenesis and cell cycle. Quantitative real-time PCR was performed to verify the top-five circRNAs. ROC analysis showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively. Our results suggest the circRNA-miRNA-mRNA network may help us further understand the molecular mechanisms of tumor progression in liver cancer, and reveal novel biomarkers and therapeutic targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据