期刊
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
卷 21, 期 6, 页码 606-612出版社
ELSEVIER BRAZIL
DOI: 10.1016/j.bjid.2017.07.002
关键词
Pulmonary infection; HIV/AIDS; (1-3)-beta-D-Glugan; LDH; LAMP; Pneumocystosis; Fungal infectiona
资金
- Science and Technology Research Partnership for Sustainable Development, Japan (SATREPS)
- University of Campinas, Brazil [02P-29548-09]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, FAPESP [2012/51158-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/51158-0] Funding Source: FAPESP
Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients' serums were tested for (1-3)-beta-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis. Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-beta-D-Glucan level (mean: 241 pg/mL) and lactate dehydrogenase (mean: 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients. Conclusion: In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-beta-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda.
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