期刊
CURRENT FUNGAL INFECTION REPORTS
卷 11, 期 4, 页码 190-196出版社
SPRINGER
DOI: 10.1007/s12281-017-0298-1
关键词
Heteroresistance; Cryptococcus neoformans; Cryptococcus gattii; Antifungal resistance; Fluconazole
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [2013/04567-5]
Purpose of Study To review the literature on heteroresistance to fluconazole (FLC) and investigate the level of heteroresistance to FLC (LHF), we analyzed 100 clinical and environmental Brazilian Cryptococcus strains. Recent Findings Heteroresistance is a phenomenon described as the emergence of resistant subpopulation cells within a single susceptible strain that can tolerate higher concentrations of fluconazole above the minimal inhibitory concentration (MIC) level. Summary We found lower FLC-MICs (0.12-64 mg/L) than LHF (8-128 mg/L). Highly heteroresistant adapted subpopulations (256 mg/L) was found in minority (9%) strains, but importantly, 33% showed low FLC-MIC (8 mg/L). We concluded for similar LHF in both species, but higher LHF in clinical strains in comparison to environmental ones. Our findings stressed that the LHF is not correlated to species and pretty is strain-dependent and alert about high heteroresistant subpopulations that hardly reverts to the original LHF even upon the removal of drug pressure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据