期刊
BIOSCIENCE REPORTS
卷 37, 期 -, 页码 -出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSR20171021
关键词
-
资金
- Scientific Research Foundation of the First Affiliated Hospital of Jinan University [2015210]
- Science and Technology Program of Guangzhou [A2016040]
- Natural Science Foundation of Guangdong [2016ZC0042, 2016ZC0048]
- National Scientific Research Foundation [21615473]
- Science and Technology Program in Social Development of Guangzhou [2013B021400002]
Cysteine-X-cysteine ligand 8 (CXCL8) was originally discovered as a proinflammatory chemokine. Recently, CXCL8 has been shown to act as an oncogene in several types of human cancers. However, the clinical and prognostic significance of CXCL8 in cervical cancer is poorly understood. In our study, we found that CXCL8 was highly expressed in cervical cancer tissues compared with normal cervical tissues in microarray datasets (GSE9750 and GSE7803). CXCL8 mRNA and protein expressions were increased in cervical cancer tissues and cell lines compared with normal cervical tissues and cervical epithelial cell lines. CXCL8 protein expression was significantly correlated with clinical stage, distant metastasis, histological type, and histological grade. CXCL8 high expression was a poor independent prognostic parameter for cervical cancer patients. In conclusion, CXCL8 is highly expressed in cervical cancer tissues and cell lines, and correlated with malignant status and prognosis in cervical cancer patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据