期刊
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
卷 3, 期 3, 页码 331-338出版社
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2017.01.013
关键词
Gastric Cancer; Stem Cell; Stem Cell Niche; Lgr5; Mist1; CCK2R
资金
- National Institute of Health [U54CA126513, R01CA093405, R01CA120979, R01DK052778, R35CA210088, T32OD010978, P30ES002109, P01CA28842]
- Clyde Wu Family Foundation
- Project for Cancer Research And Therapeutic Evolution (P-CREATE) from the Japan Agency of Medical Research and Development, AMED
- Japan Society for the Promotion of Science
- Kobayashi Foundation for Cancer Research
- Mochida Memorial Foundation for Medical and Pharmacological Research
- Tokyo Society of Medical Sciences
- Grants-in-Aid for Scientific Research [16H06749] Funding Source: KAKEN
In this perspective, we briefly summarize recent advances in our understanding of gastric stem cells and their link to gastric cancer. Although the discussion is focused largely on mouse experimental models and the gastric mucosa, we correlate experimental observations with human studies as well as findings from other cancer fields, most of which have pointed to stem cells as the origin of cancer. We also comment on the role of alterations in the stem cell niche as fundamental to the development of gastric cancer. Although other gastric cell types may possess some degree of cellular plasticity and could contribute to cancer development, accumulating evidence indicates that stem cells are the major cellular origin of most cancers, including gastric cancer. The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular origin of cancer. During gastric carcinogenesis, chronic inflammation induces genetic and epigenetic alterations in long-lived stem cells, along with expansion of stem cell niches, eventually leading to invasive cancer. The gastric corpus and antrum have distinct stem cells and stem cell niches, suggesting differential regulation of cancer initiation at the 2 sites. In this short review, we discuss recent experimental models and human studies, which provide important insights into the pathogenesis of gastric cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据