期刊
GUT MICROBES
卷 8, 期 4, 页码 374-383出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2017.1290758
关键词
bacteroides; competition; pathogenesis; secretion; toxin
资金
- Burroughs Wellcome Foundation Investigators in the Pathogenesis of Infectious Disease Fellowship
- National Institutes of Health Medical Scientist Training Program at the University of Chicago [GM007281]
- Department of Pediatrics at the University of Chicago
- Pilot and Feasibility Award from the Digestive Diseases Research Core Center at the University of Chicago [NIDDK P30DK42086]
The mature microbiome is a stable ecosystem that resists perturbation despite constant host exposure to exogenous microbes. However, the microbial mechanisms determining microbiome development and composition are poorly understood. We recently demonstrated that a non-toxigenic B. fragilis (NTBF) strain restricts enteric colonization by an enterotoxigenic (ETBF) strain dependent on a type VI secretion system (T6SS). We show here that a second enterotoxigenic strain is competent to colonize, dependent on the Bacteroides fragilis pathogenicity island (BFPAI). Additional data showing complex environmental regulation of the Bacteroides fragilis toxin (BFT) suggest that virulence factors may be adapted to modify the colonic niche to provide a strain-specific colonization advantage. We conclude that more complex models of host-microbe-microbiome interactions are needed to investigate this hypothesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据