期刊
GUT MICROBES
卷 8, 期 4, 页码 384-391出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2017.1290759
关键词
bacteriocin; intestinal barrier; Listeria monocytogenes; Listeriolysin S; LLS; microbiota
资金
- L'Agence Nationale de la Recherche [ANR-15-CE15-0017 StopBugEntry]
- Fondation Le Roch Les Mousquetaires
- European Research Council Advanced Grant [670823 BacCellEpi]
- Region Ile-de-France (DIM-MALINF)
- Institut Pasteur
- Institut National de la Sante et de la Recherche Medicale (INSERM Unite) [604]
- Institut National de la Recherche Agronomique (INRA Unite Sous Contrat)
- Institut Pasteur 'Programmes Transversaux de Recherche' [PTR521]
Listeria monocytogenes is a Gram-positive food-borne pathogen that in humans may traverse the intestinal, placental and blood/brain barriers, causing gastroenteritis, abortions and meningitis. Crossing of these barriers is dependent on the bacterial ability to enter host cells, and several L. monocytogenes surface and secreted virulence factors are known to facilitate entry and the intracellular lifecycle. The study of L. monocytogenes strains associated to human listeriosis epidemics has revealed the presence of novel virulence factors. One such factor is Listeriolysin S, a thiazole/oxazole modified microcin that displays bactericidal activity and modifies the host microbiota during infection. Our recent results therefore highlight the interaction of L. monocytogenes with gut microbes as a crucial step in epidemic listeriosis. In this article, we will discuss novel implications for this family of toxins in the pathogenesis of diverse medically relevant microorganisms.
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