期刊
STEROIDS
卷 121, 期 -, 页码 17-21出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2017.03.001
关键词
Aging; Menopause; Adipose tissue; Estrogen receptor gene expression
资金
- National Institutes of Health, United States [R01 DK077992, R01 DK088105, P50 HD073063, T32 DK007446, P30 DK048520, UL1 TR000154]
Objectives: Changes in estrogen receptor (ER) expression likely underlie differential metabolic effects of estrogen in pre- and postmenopausal women. The aim of the current study was to determine whether ER gene expression in abdominal and femoral subcutaneous adipose tissue (SAT) was associated with age, menopause, or regional adiposity. Methods: We studied pre- and post-menopausal (n = 23 and 22, respectively; age 35-65 y) normal weight (mean +/- SD; BMI 23.7 +/- 2.5 kg/m(2)) women with similar total fat mass. Abdominal and femoral SAT ER alpha (ESR1) and ER beta (ESR2) mRNA expression was determined by qPCR. Results: Total fat mass did not differ between pre- and postmenopausal women (22.7 +/- 5.3 vs. 21.7 +/- 5.3 kg). Compared to premenopausal women, ESR1 and the ratio of ESR1 to ESR2 were lower (p <= 0.05) in postmenopausal abdominal and femoral SAT. ESR1 and ESR1':ESR2 were inversely associated with age in abdominal SAT (r = -0.380 and r = -0.463, respectively; p < 0.05) and femoral SAT (r = -0353 and r = -0.472, respectively; p < 0.05). ESR2 was not related to age or menopause. The inverse association between ESR1 and age persisted after adjusting for trunk fat mass, estradiol, or leptin. Conclusion: Among healthy pre- and postmenopausal women, increased age was associated with a decreased balance of ERa to ER beta in abdominal and femoral subcutaneous adipose tissue. (C) 2017 Elsevier Inc. All rights reserved.
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