期刊
EPILEPSIA
卷 56, 期 7, 页码 e95-e98出版社
WILEY-BLACKWELL
DOI: 10.1111/epi.13038
关键词
Epilepsy; FIRES; IL-1 beta; Ketogenic diet; Polyunsaturated fatty acids
资金
- INSERM
- INSERM, Universite Paris-Diderot
- Association INJENO
The ketogenic diet (KD) is an established treatment for refractory epilepsy, including some inflammation-induced epileptic encephalopathies. In a lipopolysaccharide (LPS)-induced fever model in rats, we found that animals given the KD for 14days showed less fever and lower proinflammatory cytokine levels than control animals. However, KD rats exhibited a decrease in circulating levels of arachidonic acid and long-chain n-3 polyunsaturated fatty acids (PUFAs), suggesting that the anti-inflammatory effect of KD was probably not due to an increase in anti-inflammatory n-3 PUFA derivatives. These properties might be of interest in some conditions such as fever-induced refractory epileptic encephalopathy in school-aged children.
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