4.2 Article

Human spermatogonial markers

期刊

STEM CELL RESEARCH
卷 25, 期 -, 页码 300-309

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.scr.2017.11.011

关键词

Spermatogonia; Stem cells; Gene expression; Microarray; RNA sequencing

资金

  1. DFG [KO 4769/2-1, SP 721/4-1]

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In this review, we provide an up-to-date compilation of published human spermatogonial markers, with focus on the three nuclear subtypes A(dark), A(pale) and B. In addition, we have extended our recently published list of putative spermatogonial markers with protein expression and RNA-sequencing data from the Human Protein Atlas and supported these by literature evidence. Most importantly, we have put substantial effort in acquiring a comprehensive list of new and potentially interesting markers by refiltering the raw data of 15 published germ cell expression datasets (four human, eleven rodent) and subsequent building of intersections to acquire a robust, cross-species set of spermatogonia-enriched or -specific transcripts. (C) 2017 The Author(s). Published by Elsevier B.V.

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