期刊
STEM CELL RESEARCH
卷 21, 期 -, 页码 193-201出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scr.2017.04.008
关键词
Germ cell differentiation; RNA binding proteins; LIN28; DAZL; BOLL; FMRP
资金
- Medical Research Council [G1100357]
- Medical Research Scotland [354FRG]
- Royal Society [RG140503]
- Medical Research Council [G1002118, G1100357] Funding Source: researchfish
- MRC [G1002118, G1100357] Funding Source: UKRI
Primordial germ cells undergo three significant processes on their path to becoming primary oocytes: the initiation of meiosis, the formation and breakdown of germ cell nests, and the assembly of single oocytes into primordial follicles. However at the onset of meiosis, the germ cell becomes transcriptionally silenced. Consequently translational control of pre-stored mRNAs plays a central role in coordinating gene expression throughout the remainder of oogenesis; RNA binding proteins are key to this regulation. In this review we examine the role of exemplars of such proteins, namely LIN28, DAZL, BOLL and FMRP, and highlight how their roles during germ cell development are critical to oogenesis and the establishment of the primordial follicle pool. (C) 2017 The Authors. Published by Elsevier B.V.
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