期刊
STEM CELL RESEARCH
卷 19, 期 -, 页码 104-112出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scr.2017.01.008
关键词
Pluripotent stem cells; Mouse; Rat; Rabbit; Primate
资金
- Agence Nationale de la Recherche (ANR) [PCS-09-GENM-08, ANR-12-RPIB-0013]
- European Cooperation in Science and Technology (COST) Action (Rabbit Genome Biology (RGB)-Net) [TD1101]
- HyPharm
- Region Rhone-Alpes (ADR CIBLE) [R10065CC]
- Infrastructure Nationale en Biologie et Sante INGESTEM [ANR-11-INBS-0009]
- Infrastructure Nationale en Biologie et Sante CRB-Anim [ANR-11-INBS-0003]
- IHU-B CESAME [ANR-10-IBHU003]
- LabEx DEVweCAN [ANR-10-LABX-0061]
- LabEx CORTEX of the University of Lyon within the program Investissements d'Avenir [ANR-11-LABX-0042, ANR-11-IDEX-0007]
- Fondation pour la Recherche Medicale [FRM SPE20140129375]
- NMHRC of Australia [1003100, 111075]
- Agence Nationale de la Recherche (ANR) [ANR-12-RPIB-0013] Funding Source: Agence Nationale de la Recherche (ANR)
The diverse cell states and in vitro conditions for the derivation and maintenance of the mammalian embryo-derived pluripotent stem cells raise the questions of whether there are multiple states of pluripotency of the stem cells of each species, and if there are innate species-specific variations in the pluripotency state. We will address these questions by taking a snapshot of our knowledge of the properties of the pluripotent stem cells, focusing on the maintenance of pluripotency and inter-conversion of the different types of pluripotent stem cells from rodents, lagomorphs and primates. We conceptualize pluripotent stem cells acquiring a series of cellular states represented as terraces on a slope of descending gradient of pluripotency. We propose that reprogramming pluripotent stem cells from a primed to a naive state is akin to moving upstream over a steep cliff to a higher terrace. (C) 2017 The Authors. Published by Elsevier B.V.
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