期刊
EPIDEMIOLOGY AND INFECTION
卷 143, 期 15, 页码 3266-3276出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268815000539
关键词
CTX-M-15; extraintestinal pathogenic Escherichia coli; neonatal sepsis; serotypes; ST131; virulence factors; India
资金
- Indian Council of Medical Research (ICMR) intramural fund
- ICMR
The study characterizes a collection of 67 neonatal septicaemic Escherichia coli isolates on the basis of phylogroup, serotype, virulence, antibiotic resistance and also the association of CTX-M-producing E. coli and the ST131 clone in a developing country. Phylogroups B2 and D were predominant (33% and 19%, respectively). The most prevalent virulence factors (VFs) were traT (69%) and iucC (68%) and most VFs were concentrated in the B2 isolates. High levels of resistance (70%) to cefotaxime, ciprofloxacin and trimethoprim/sulfamethoxazole was recorded but meropenem remained the most active antimicrobial. Six (9%) of the study isolates belonged to the ST131 clone, five of which were from the same hospital, and were either indistinguishable or closely related by pulsed-field gel electrophoresis. Although the prevalence of CTX-M-15-producing isolates was high (81%), the ST131 clone was relatively infrequent (11%) in extended spectrum -lactamase (ESBL)-producers. The ST131 clone was characterized by the presence of bla(CTX-M-15), qnrS, aac(6)-Ib-cr, IncF plasmids and virulence determinants such as iucC, papC, traT, usp, hlyA, iroN(E.coli), cnf, and sat. We conclude that clonal spread of ST131 did not contribute directly to the high prevalence of CTX-M-15 in our settings.
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