期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 39, 期 1, 页码 447-456出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2014.12.013
关键词
Direct equipartition ray design; Short-term toxicity; Long-term toxicity; Synergism; Microplate toxicity analysis
资金
- National Natural Science Foundation of China [21177097]
- Specialized Research Fund for the Doctoral Program of Higher Education [20120072110052]
It is necessary to explore the effect of confidence intervals on the combination index (CI) so that rationally evaluate the toxicological interaction (synergism or antagonism) which is dependent on the concentration ratio, the mixture concentration and the exposure time. To effectively detect the toxicological interaction taking place in mixtures, we combined the CI with the observation-based confidence intervals (OCI) which can characterize the uncertainty in toxicity test and in data fitting. In time scale, the short-term (15 min) and long-term (12h) toxicities of three chemicals (imidacloprid (IMI), pirimicarb (FIR) and streptomycin sulfate (STR)) and their binary mixtures on Vibrio qinghaiensis sp.-Q67 were determined by the microplate toxicity analysis (MTA). The mixtures of IMI, FIR and STR have additive actions all but four IMI-PIR rays (R2-R5) at the effect levels above about 30-40% whose long-term toxicological interaction are synergism. (C) 2014 Elsevier B.V. All rights reserved.
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