期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 40, 期 3, 页码 747-757出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2015.08.035
关键词
Chemoprotection; Cyclophosphamide; Oxidative stress; Histopathology; DNA damage; Apoptosis
资金
- Indian Council of Medical Research (ICMR), New Delhi, India [3/2/2/58/2011/NCD-III]
- ICMR [45/36/2008/PHA-BMS]
Vanadium has been emerged as a promising agent owing to its ability to prevent several types of cancer. This study was aimed to investigate the protective role of an organovanadium complex, viz., oxovanadium(IV)-L-cysteine methyl ester (VC-IV) against cyclophosphamide (CP)-induced hepatotoxicity and genotoxicity in mice. Oral administration of VC-IV quite effectively ameliorated CP-induced histopathological lesions and reduced levels of alanine transaminase,aspartate transaminase and alkaline phosphatase. In addition, VC-IV significantly attenuated CP-induced oxidative stress in the liver as evident from levels of reactive oxygen species, nitric oxide and lipid peroxidation. Restoration of glutathione level and activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase) were also observed upon VC-IV administration. Moreover, VC-IV significantly mitigated CP-induced chromosomal aberrations, micronuclei formation, DNA fragmentation and apoptosis in bone marrow cells and DNA damage in lymphocytes. The present study showed that VC-IV could provide adequate protection against CP-induced hepatotoxicity and genotoxicity in vivo. (C) 2015 Elsevier B.V. All rights reserved.
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