期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 40, 期 3, 页码 924-930出版社
ELSEVIER
DOI: 10.1016/j.etap.2015.09.020
关键词
Obesity; Low-level chronic inflammation; Osmotic pump; Influenza virus
资金
- Korean Healthcare Technology R&D project of the Ministry of Health Welfare [A103001, HI13C0826]
- Basic Science Research, Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2015M3A9B5030116]
- Gyunggi Regional Research Center (GRRC) of the Catholic University of Korea
Obese individuals show increased susceptibility to infection, low vaccine efficacy, and worse pathophysiology. However, it is unclear how obesity affects these events. The aim of this study was to investigate the effect of obesity-triggered chronic inflammation on immune cells after influenza virus infection. Control and lipopolysaccharide mice, in which an osmotic pump continually released Tween saline or lipopolysaccharide, were prepared and 3 weeks later were infected with pandemic H1N1 2009 influenza A virus. In lipopolysaccharide mice, we found a reduction in macrophage activation markers in the steady state, and reduced production of pro-inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6, in restimulated peritoneal macrophages. Interestingly, lipopolysaccharide-triggered chronic inflammation exacerbated the severity of pathological symptoms in the lungs after challenge with influenza virus. Taken together, the increased severity of virus-induced symptoms in obese individuals with chronic inflammation may be, at least partially, caused by macrophage dysfunction. (C) 2015 Elsevier B.V. All rights reserved.
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