期刊
NPJ PRECISION ONCOLOGY
卷 1, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41698-017-0041-y
关键词
-
类别
资金
- National Natural Science Foundation of China [81372282, 81071718, 81402368, 81402265, 81502346]
- Program for New Century Excellent Talents in University, NCET [NCET-06-0685]
- Guangdong Natural Science Foundation [S2013010013360]
- China Postdoctoral Science Foundation [2016M592580]
Nucleic acid aptamers are a class of high-affinity nucleic acid ligands. They serve as chemical antibodies since their high affinity and specificity. Nucleic acid aptamers are generated from nucleic acid random-sequence using a systematic evolution of ligands by exponential enrichment (SELEX) technology. SELEX is a process of effectively selecting aptamers from different targets. A newly developed cell-based SELEX technique has been widely used in biomarker discovery, early diagnosis and targeted cancer therapy, particular at colorectal cancer (CRC). Combined with nanostructures, nano-aptamer-drug delivery system was constructed for drug delivery. Various nanostructures functionalized with aptamers are highly efficient and has been used in CRC therapeutic applications. In the present, we introduce a cell-SELEX technique, and summarize the potential application of aptamers as biomarkers in CRC diagnosis and therapy. And some characteristics of aptamer-targeted nanocarriers in CRC have been expatiated. The challenges and perspectives for cell-SELEX are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据