期刊
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
卷 35, 期 4, 页码 788-793出版社
WILEY
DOI: 10.1002/etc.3063
关键词
Ecotoxicology; Endocrine-disrupting chemicals; Pharmaceuticals; microRNA; Fluoxetine
资金
- Natural Sciences and Engineering Council of Canada
- University of Ottawa Research Chair in Neuroendocrinology
Micro ribonucleic acids (miRNAs) are recently discovered small regulatory molecules that control messenger RNA (mRNA) translation in plants and animals and have been implicated in a variety of hormone-related physiological pathways. Estrogens, thyroid hormones, and gonadotropins are all known to act on miRNA abundance to cause major shifts in cellular activity, physiology, and homeostatic control mechanisms. Research on cancer biology has also recently considered miRNA as therapeutic targets, because the deregulation of specific miRNAs in various tissues has been correlated with tumorigenesis and other carcinogenic responses. Because many pharmaceuticals are considered to be endocrine-disrupting chemicals (EDCs), their effects on miRNAs may be important to our understanding of basic physiological control and phenotypic outcomes of wildlife exposed to EDCs. Presented is a brief overview of the synthesis, control, and action of miRNAs, focusing on endocrine systems. The antidepressant fluoxetine will be used as an example for miRNA studies in aquatic species, one of the few examples in ecotoxicology. Given the mounting evidence that miRNAs are regulated by hormones, a clear need exists to investigate the potential for environmental EDCs to deregulate miRNA expression and action. (C) 2015 SETAC
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