期刊
SMALL
卷 13, 期 29, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201701201
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资金
- Estonian Research Agency [PUT748]
- European Regional Development Fund [TK134]
- FEDER region Languedoc Roussillon
There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody-functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two-stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity.
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