期刊
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
卷 34, 期 12, 页码 2703-2714出版社
WILEY
DOI: 10.1002/etc.3242
关键词
Bioaccumulation; Biomagnification; Trophic magnification
资金
- Silicones Environmental Health and Safety Center (SEHSC)
Decamethylpentacyclosiloxane (D5) is a widely used, high-production volume personal care product with an octanol-water partition coefficient (logK(OW)) of 8.09. Because of D5's high K-OW and widespread use, it is subject to bioaccumulation assessments in many countries. The present study provides a compilation and an in-depth, independent review of bioaccumulation studies involving D5. The findings indicate that D5 exhibits depuration rates in fish and mammals that exceed those of extremely hydrophobic, nonbiotransformable substances; that D5 is subject to biotransformation in mammals and fish; that observed bioconcentration factors in fish range between 1040 L/kg and 4920 L/kg wet weight in laboratory studies using non-radiolabeled D5 and between 5900 L/kg and 13 700 L/kg wet weight in an experiment using C-14 radiolabeled D5; and that D5 was not observed to biomagnify in most laboratory experiments and field studies. Review of the available studies shows a high degree of internal consistency among findings from different studies and supports a broad comprehensive approach in bioaccumulation assessments that includes information from studies with a variety of designs and incorporates multiple bioaccumulation measures in addition to the K-OW and bioconcentration factor. Environ Toxicol Chem 2015;34:2703-2714. (c) 2015 The Authors. Environmental Toxicology and Chemistry Published by Wiley Periodicals, Inc. on behalf of SETAC.
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