期刊
SMALL
卷 13, 期 17, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201603459
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资金
- Natural Science Foundation of China [21675090, 21435001]
- National Basic Research Program of China (973 Program) [2015CB932001]
- Research Fund for the Doctoral Program of Higher Education [20130031110016]
- Tianjin Natural Science Foundation [15ZCZDSF00060, 15JCYBJC24400]
Imaging-guided therapy systems (IGTSs) are revolutionary techniques used in cancer treatment due to their safety and efficiency. IGTSs should have tunable compositions for bioimaging, a suitable size and shape for biotransfer, sufficient channels and/or pores for drug loading, and intrinsic hiocompatibility. Here, a hiocompatible nanoscale zirconium-porphyrin metal organic framework (NPMOF)-based IGTS that is prepared using a microemulsion strategy and carefully tuned reaction conditions is reported. A high content of porphyrin (59.8%) allows the achievement of efficient fluorescent imaging and photodynamic therapy (PDT). The ID channel of the Kagome topology of NPMOFs provides a 109% doxorubicin loading and pH-response smart release for chemotherapy. The fluorescence guiding of the chemotherapy-and-PDT dual system is confirmed by the concentration of NPMOFs at cancer sites after irradiation with a laser and doxorubicin release, while low toxicity is observed in normal tissues. NPMOFs are established as a promising platform for the early diagnosis of cancer and initial therapy.
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