期刊
SMALL
卷 13, 期 19, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201603679
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资金
- European Research Council for European Union [311529]
- Grassroots Initiative from Max Planck Institute for Intelligent Systems
- European Research Council (ERC) [311529] Funding Source: European Research Council (ERC)
- ICREA Funding Source: Custom
Bacteria biohybrids employ the motility and power of swimming bacteria to carry and maneuver microscale particles. They have the potential to perform microdrug and cargo delivery in vivo, but have been limited by poor design, reduced swimming capabilities, and impeded functionality. To address these challenge, motile Escherichia coli are captured inside electropolymerized microtubes, exhibiting the first report of a bacteria microswimmer that does not utilize a spherical particle chassis. Single bacterium becomes partially trapped within the tube and becomes a bioengine to push the microtube though biological media. Microtubes are modified with smart material properties for motion control, including a bacteria-attractant polydopamine inner layer, addition of magnetic components for external guidance, and a biochemical kill trigger to cease bacterium swimming on demand. Swimming dynamics of the bacteria biohybrid are quantified by comparing length of protrusion of bacteria from the microtubes with respect to changes in angular autocorrelation and swimmer mean squared displacement. The multifunctional microtubular swimmers present a new generation of biocompatible micromotors toward future microbiorobots and minimally invasive medical applications.
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