期刊
SMALL
卷 14, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201702815
关键词
black phosphorus; photodynamic therapy; photosensitizers; quantum dots; renal clearance
类别
资金
- National Natural Science Foundation of China [U1505221, 21635002, 81501461]
- Natural Science Foundation of Fujian Province of China [2015H6011]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT15R11]
- Independent Research Project of State Key Laboratory of Photocatalysis on Energy and Environment [2014B02]
Black phosphorus (BP) nanomaterials have emerged as rapidly rising stars in the field of nanomedicine. In this work, BP quantum dots (BPQDs) are synthesized and their potential as photosensitizers is investigated for the first time. The BPQDs present good stability in physiological medium and no appreciable cytotoxicity. More importantly, the BPQDs can be rapidly eliminated from the body in their intact form via renal clearance due to their ultrasmall hydrodynamic diameter (5.4 nm). Both in vitro and in vivo studies indicate that the BPQDs have excellent photodynamic effect under light irradiation that can effectively generate reactive oxygen species to kill cancer cells. The BPQDs thus can serve as biocompatible and powerful photosensitizers for efficient photodynamic therapy.
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