期刊
SMALL
卷 13, 期 37, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201701300
关键词
image-guided surgery; indocyanine green; magnetic resonance imaging; photoacoustic imaging; superparamagnetic iron oxide
类别
资金
- NIH/NIBIB [U01-EB016027]
- NIH/NCI [R01-CA181429, R01-CA175480]
- Radiological Society of North America Research and Education Foundation
- Neurosurgery Research and Education Foundation Research Fellowship
A common cause of local tumor recurrence in brain tumor surgery results from incomplete surgical resection. Adjunctive technologies meant to facilitate gross total resection have had limited efficacy to date. Contrast agents used to delineate tumors preoperatively cannot be easily or accurately used in the real-time operative setting. Although multimodal imaging contrast agents are developed to help the surgeon discern tumor from normal tissue in the operating room, these contrast agents are not readily translatable. This study has developed a novel contrast agent comprised solely of two Food and Drug Administration approved components, indocyanine green (ICG) and superparamagnetic iron oxide (SPIO) nanoparticleswith no additional amphiphiles or carrier materials, to enable preoperative detection by magnetic resonance (MR) imaging and intraoperative photoacoustic (PA) imaging. The encapsulation efficiency of both ICG and SPIO within the formulated clusters is approximate to 100%, and the total ICG payload is 20-30% of the total weight (ICG + SPIO). The ICG-SPIO clusters are stable in physiologic conditions; can be taken up within tumors by enhanced permeability and retention; and are detectable by MR. In a preclinical surgical resection model in mice, following injection of ICG-SPIO clusters, animals undergoing PA-guided surgery demonstrate increased progression-free survival compared to animals undergoing microscopic surgery.
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