期刊
SLEEP MEDICINE
卷 29, 期 -, 页码 29-34出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.sleep.2016.09.012
关键词
Coronary artery disease; Sleep disorders; Inflammation
资金
- Grants-in-Aid for Scientific Research [16K15415] Funding Source: KAKEN
Background: Sleep-disordered breathing (SDB) or short sleep duration and coronary artery disease (CAD) are related, yet, the prevalence of SDB and short sleep duration as well as their mechanism remain unknown. Enhanced vascular inflammation is also implicated as one of the pathophysiologic mechanisms in CAD. The aims of this study were to evaluate the prevalence of patients with SDB and short sleep duration, and to examine their relationship with serum C-reactive protein (CRP) level in CAD patients. Methods and results: We evaluated 161 CAD patients who underwent percutaneous coronary intervention, using nocturnal pulse oximetry, a non-invasive screening method for nocturnal intermittent hypoxia. Based on three percent oxygen desaturation index (3% ODI), the patients were divided into nocturnal intermittent hypoxia (3% ODI >= 15; n = 45) and control groups (3% ODI < 15, n = 116). The nocturnal intermittent hypoxia group had higher body mass index and serum CRP level compared with the control group. Short sleep duration (>= 6 h, n = 45) was also associated with increased CRP level compared with the control group (>= 6 h, n = 116). In multiple regression analysis, nocturnal intermittent hypoxia (beta = 0.332, 95% confidence interval [CI] 0.102-0.562, P = 0.005) and short sleep duration (beta = 0.311, 95% CI 0.097-0.526, P = 0.005) were both independent determinants for log serum CRP level. Conclusions: Nocturnal intermittent hypoxia and short sleep duration were independently associated with elevated serum CRP level in CAD patients, suggesting that both SDB and sleep shortage are associated with enhanced inflammation in CAD patients. SDB and sleep duration may be important modifiable factors in the clinical management of patients with CAD. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据