期刊
SKIN PHARMACOLOGY AND PHYSIOLOGY
卷 30, 期 2, 页码 55-65出版社
KARGER
DOI: 10.1159/000455196
关键词
Pig; Human; Standardized model; Tape stripping; Barrier-disrupted skin model; Bioavailability; Sunscreen filters
Background: Information is lacking on the dermal penetration of topically applied formulations on in vitro skin models, under conditions where the stratum corneum (SC) is damaged. Therefore, we have developed a standardized in vitro barrier-disrupted skin model using tape stripping. Methods: Different tape stripping conditions were evaluated using histology, transepidermal water loss, infrared densitometry, and caffeine absorption. Results: The effects of tape stripping were comparable using pig and human skin. Optimized conditions were used to test the effect of SC damage and UV irradiation on the absorption of an UV filter combination present in a sunscreen. The bioavailability of the filters was extremely low regardless of the extent of skin damage, suggesting bioavailability would not be increased if the consumer applied the sunscreen to sun-damaged skin. Conclusion: This standardized in vitro methodology using pig or human skin for damaged skin will add valuable information for the safety assessment of topically applied products. (C) 2017 S. Karger AG, Basel
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