3.8 Proceedings Paper

Structural features of the ionic self-complementary amyloidogenic peptide

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IOP PUBLISHING LTD
DOI: 10.1088/1742-6596/848/1/012022

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  1. Russian state 5-100 Russian Academic Excellence Project for enhancing the competitiveness of MIPT among the world's leading research and education centres of the Ministry of education and science
  2. Russian Science Foundation [14-13-01301]
  3. Russian Science Foundation [14-13-01301] Funding Source: Russian Science Foundation

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In this study we investigate the effect of triazavirine on ionic self-complementary (iSCM) containing peptides fibrils with transmission electron microscopy (TEM), small-angle neutron scattering (SANS) and MALDI mass-spectrometry (MS). It was shown that triazavirine is capable to dissociate iSCM amyloid fibrils. The mechanism of such an action is proposed.

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