期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 247, 期 -, 页码 736-741出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.03.049
关键词
Ratiometric; Fluorescent probe; Forster resonance energy transfer; Hypochlorous acid; Bioimaging
资金
- Natural Science Foundation of Shandong Province [ZR2014BM004]
- Major Project of Science and Technology of Shandong Province [2015ZDJS04001, 2015ZDJS04003]
A ratiometric fluorescent probe (DICX) based on Forster resonance energy transfer (FRET) system for hypochlorous acid (HOCl) was developed, in which coumarin moiety was connected to rhodamine by monothio-bishydrazide linker. DICX could fast respond to HOCl under acidic condition and showed high selectivity and sensitivity toward HOCl over other reactive oxygen species, reactive nitrogen species, and ions. The FRET energy transfer efficiency is very high (93.75%). Moreover, DICX could target lysosome and could be suitable for sensing exogenous and endogenous HOCl in living cells. (C) 2017 Elsevier B.V. All rights reserved.
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