期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 242, 期 -, 页码 71-78出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2016.11.036
关键词
Electrochemical sensors; Ratiometric; Bare electrode; Electrolyte solution; Doxorubicin
资金
- National Natural Science Foundation of China [21475071, 21405086, 21275082]
- Taishan Scholar Program of Shandong [ts201511027]
- Natural Science Foundation of Shandong, China [ZR20148Q001, BS2014NJ023]
- Qingdao Postdoctoral Applied Research Project [2015136]
In this work, a general strategy to facilely fabricate novel dual-ratiometric (PR) electrochemical sensors (ECSs) was developed. This strategy referred to three types of substances with respective oxidation current peaks at different electric potentials, such as ferrocene (Fc) at 0.15 V, methylene blue (MB) at -0.26 V, and doxorubicin (DOX) at -0:62 V. In a conventional electrolyte solution of phosphate buffered saline (0.01 M, pH 6.5, containing 0.15 M of NaCl), Fc and MB as reference electroactive substances were added and their concentrations in electrolyte solution were fixed to 30 and 4 mu M, respectively. Then, DOX as the analyte was also added into the electrolyte solution to form a homogeneous electrolyte solution. Through directly using a bare glassy carbon electrode as dual-signal sensing platform, square wave voltammetry curves of various electrolyte solutions containing three components of different concentrations were measured, with the each increment of DOX concentration [DOX] from 0.01 to 6 mu M. Ratiometric oxidation current peak intensities (I-DOX/I-Fc or I-DOX/I-MB) nearly linearly enhanced with the increase of [DOX], together with good linear coefficients and low limits of detection (3 nM). The DR-ECSs enabled highly selective and sensitive DOX detection in real human serum and saliva samples with high detection recoveries. These results revealed that this strategy to fabricate novel DR-ECSs was facile and flexible, which would facilitate a further development in the field of electrochemical sensing. (C) 2016 Elsevier B.V. All rights reserved.
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