期刊
REGENERATIVE BIOMATERIALS
卷 4, 期 5, 页码 325-334出版社
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbx025
关键词
wound healing; tissue-engineered skin; bioderived materials; acellular matrix
资金
- National Key Research and Development Program of China [2017YFC1104702]
- National Natural Science Foundation of China [31600792, 31771065]
Treatment of acute and chronic wounds is one of the primary challenges faced by doctors. Bioderived materials have significant potential clinical value in tissue injury treatment and defect reconstruction. Various strategies, including drug loading, addition of metallic element(s), cross-linking and combining two or more distinct types of materials with complementary features, have been used to synthesize more suitable materials for wound healing. In this review, we describe the recent developments made in the processing of bioderived materials employed for cutaneous wound healing, including newly developed materials such as keratin and soy protein. The focus was on the key properties of the bioderived materials that have shown great promise in improving wound healing, restoration and reconstruction. With their good biocompatibility, nontoxic catabolites, microinflammation characteristics, as well as their ability to induce tissue regeneration and reparation, the bioderived materials have great potential for skin tissue repair.
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