期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 241, 期 -, 页码 1194-1202出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2016.10.014
关键词
Omeprazole; Boron-doped diamond electrode; Voltammetry; Urine; Pharmaceuticals
资金
- GAPF Agency of Faculty of Education, The Catholic University in Ruzomberok [GAPF 1/19/2015]
Voltammetric behavior of omeprazole on chemically unmodified boron-doped diamond electrode was investigated. Omeprazole is possible to oxidize and reduce in various supporting electrolytes. Both processes are strongly dependent on pH value of the solution. Well defined oxidation and reduction signal of omeprazole was observed at high and low pH values of supporting electrolyte. Kinetics of charge transfer in the pH range from 3 to 10 in various supporting electrolytes was studied and characterized by the estimation of formal potentials (+1.07 to +0.89 V for oxidation and -0.95 to -1.18 V for omeprazole reduction), charge transfer coefficients (0.52-0.33 for oxidation and 0.19-0.17 for reduction) together with standard heterogeneous rate constants. The analytical performance was studied with linear sweep voltammetry, square-wave voltammetry and differential pulse voltammetry. The lowest detection limit of 9.1 x 10(-8) mol L-1 for oxidation of omeprazole was achieved by SWV technique. The proposed simple, sensitive and cheap method was validated and applied for pharmaceutical formulations and human urine as real samples. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据