期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 22, 期 24, 页码 20167-20176出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-015-5222-z
关键词
PM2.5; Rat lung injury; Inflammation; Proto-oncogene; Metabolic enzyme; Oxidative stress
资金
- National Natural Science Foundation of China [21177078]
- Environmental Protection Public Welfare Research Funds [201309009]
- Shanxi Scholarship Council of China [2013-16]
- Nature Science Foundation of Shanxi Province in China [2014011036-2]
- Foundation of Educational Committee of Shanxi Province in China [2014110]
- International Science and Technology Collaborative Project of Shanxi Province of China [2012081010]
Fine particulate matter (PM2.5) exposure is associated with morbidity and mortality induced by respiratory diseases and increases the lung cancer risk. However, the mechanisms therein involved are not yet fully clarified. In this study, the PM2.5 suspensions at different dosages (0.375, 1.5, 6.0, and 24.0 mg/kg body weight) were respectively given to rats by the intratracheal instillation. The results showed that PM2.5 exposure induced inflammatory cell infiltration and hyperemia in the lung tissues and increased the inflammatory cell numbers in bronchoalveolar lavage fluid. Furthermore, PM2.5 significantly elevated the levels of pro-inflammatory mediators including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-1 beta, and intercellular adhesion molecule 1 (ICAM-1) and the expression of c-fos and c-jun in rat lungs exposed to higher dose of PM2.5. These changes were accompanied by decreases of activities of superoxide dismutase and increases of levels of malondialdehyde, inducible nitric oxide synthase, nitric oxide, cytochrome P450s, and glutathione S-transferase. The results implicated that acute exposure to PM2.5 induced pathologically pulmonary changes, unchained inflammatory and oxidative stress processes, activated metabolic enzyme activity, and enhanced proto-oncogene expression, which might be one of the possible mechanisms by which PM2.5 pollution induces lung injury and may be the important determinants for the susceptibility to respiratory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据