期刊
SENSORS
卷 17, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/s17010080
关键词
N-type porous silicon; quantum dot labeling; QD-DNA; reflectance spectrum
资金
- National Science Foundation of China [61575168, 61665012, 11504313]
- Xinjiang Science and Technology Project [201412112]
N-type macroporous silicon microcavity structures were prepared using electrochemical etching in an HF solution in the absence of light and oxidants. The CdSe/ZnS water-soluble quantum dot-labeled DNA target molecules were detected by monitoring the microcavity reflectance spectrum, which was characterized by the reflectance spectrum defect state position shift resulting from changes to the structures' refractive index. Quantum dots with a high refractive index and DNA coupling can improve the detection sensitivity by amplifying the optical response signals of the target DNA. The experimental results show that DNA combined with a quantum dot can improve the sensitivity of DNA detection by more than five times.
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