期刊
NETWORK NEUROSCIENCE
卷 1, 期 1, 页码 14-30出版社
MIT PRESS
DOI: 10.1162/netn_a_00001
关键词
Neurodevelopment; Executive function; Energy; Entropy; Matrix factorization; Subgraph; Flexibility
资金
- Rachleff Scholars Program
- National Institutes of Health [R01-NS063039, 1U24 NS 63930-01A1]
- Citizens United for Research in Epilepsy (CURE) through a Julie's Hope Award
- Mirowski Foundation
- John D. and Catherine T. MacArthur Foundation
- Alfred P. Sloan Foundation
- Army Research Laboratory
- Army Research Office [W911NF-10-2-0022, W911NF-14-1-0679]
- National Institute of Mental Health [2-R01-DC-009209-11, MH089983]
- National Institute of Child Health and Human Development [1R01HD086888-01]
- Office of Naval Research
- National Science Foundation [BCS-1441502, BCS-1430087]
- Dowshen Program for Neuroscience
- Institute for Translational Medicine and Therapeutics at the University of Pennsylvania
- [R01MH107235]
- [P50MH096891]
- [K23MH098130]
- [R01MH107703]
Cognitive function evolves significantly over development, enabling flexible control of human behavior. Yet, how these functions are instantiated in spatially distributed and dynamically interacting networks, or graphs, that change in structure from childhood to adolescence is far from understood. Here we applied a novel machine-learning method to track continuously overlapping and time-varying subgraphs in the brain at rest within a sample of 200 healthy youth (ages 8-11 and 19-22) drawn from the Philadelphia Neurodevelopmental Cohort. We uncovered a set of subgraphs that capture surprisingly integrated and dynamically changing interactions among known cognitive systems. We observed that subgraphs that were highly expressed were especially transient, flexibly switching between high and low expression over time. This transience was particularly salient in a subgraph predominantly linking frontoparietal regions of the executive system, which increases in both expression and flexibility from childhood to young adulthood. Collectively, these results suggest that healthy development is accompanied by an increasing precedence of executive networks and a greater switching of the regions and interactions subserving these networks.
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