期刊
SENSORS
卷 17, 期 7, 页码 -出版社
MDPI AG
DOI: 10.3390/s17071580
关键词
bio-nanosensor; bacteria; nano-robot; chemotaxis; cancer therapy; microfluidics
资金
- Royal Hashemite Court under the Royal Initiative for Innovative Projects/Nanotechnology
This paper reports a novel self-detection method for tumor cells using living nano-robots. These living robots are a nonpathogenic strain of E. coli bacteria equipped with naturally synthesized bio-nano-sensory systems that have an affinity to VEGF, an angiogenic factor overly-expressed by cancer cells. The VEGF-affinity/chemotaxis was assessed using several assays including the capillary chemotaxis assay, chemotaxis assay on soft agar, and chemotaxis assay on solid agar. In addition, a microfluidic device was developed to possibly discover tumor cells through the overexpressed vascular endothelial growth factor (VEGF). Various experiments to study the sensing characteristic of the nano-robots presented a strong response toward the VEGF. Thus, a new paradigm of selective targeting therapies for cancer can be advanced using swimming E. coli as self-navigator miniaturized robots as well as drug-delivery vehicles.
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