期刊
SENSORS
卷 17, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/s17122962
关键词
surface-enhanced Raman scattering; Au nanoparticles; chloramphenicol; quantitative detection
资金
- National 973 Basic Research Program of China [2013CB733600]
- National Natural Science Foundation of China [21676015, 11405007]
- Beijing Natural Science Foundation [4142040]
We used surface-enhanced Raman scattering (SERS) for the quantitative and sensitive detection of chloramphenicol (CAP). Using 30 nm colloidal Au nanoparticles (NPs), a low detection limit for CAP of 10(-8) M was obtained. The characteristic Raman peak of CAP centered at 1344 cm(-1) was used for the rapid quantitative detection of CAP in three different types of CAP eye drops, and the accuracy of the measurement result was verified by high-performance liquid chromatography (HPLC). The experimental results reveal that the SERS technique based on colloidal Au NPs is accurate and sensitive, and can be used for the rapid detection of various antibiotics.
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