期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 52, 期 4, 页码 425-460出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2017.1325829
关键词
Ubiquitin; E3 ligase; deubiquitinase; T cell signaling; B cell signaling; TNF signaling; TRIM
资金
- ERC consolidator grant (LUbi) [614711]
- FWF standalone grant [P 25508]
- COST (European Cooperation in Science and Technology) [PROTEOSTASIS BM1307]
- Austrian Academy of Sciences
- FWF Stan-Alone grant [P 30231]
- FWF Doctoral Programme [W1261]
- European Research Council (ERC) [614711] Funding Source: European Research Council (ERC)
- Austrian Science Fund (FWF) [P30231] Funding Source: Austrian Science Fund (FWF)
Ubiquitination plays a central role in the regulation of various biological functions including immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 ubiquitin ligase, and reversed by deubiquitinases. Depending on the enzymes, specific linkage types of ubiquitin chains are generated or hydrolyzed. Because different linkage types of ubiquitin chains control the fate of the substrate, understanding the regulatory mechanisms of ubiquitin enzymes is central. In this review, we highlight the most recent knowledge of ubiquitination in the immune signaling cascades including the T cell and B cell signaling cascades as well as the TNF signaling cascade regulated by various ubiquitin enzymes. Furthermore, we highlight the TRIM ubiquitin ligase family as one of the examples of critical E3 ubiquitin ligases in the regulation of immune responses.
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