期刊
SEMINARS IN PERINATOLOGY
卷 41, 期 1, 页码 15-28出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semperi.2016.09.014
关键词
Necrotizing enterocolitis; innate intestinal immunity; adaptive intestinal immunity; pathogenesis
资金
- National Institutes of Health, United States [R01 DK097256, K23 HL128942]
- Children's Healthcare of Atlanta Friends Grant
- Emory and Children's Center for Infections and Vaccines
Necrotizing enterocolitis (NEC) is a devastating disease in premature infants with high case fatality and significant morbidity among survivors. Immaturity of intestinal host defenses predisposes the premature infant gut to injury. An abnormal bacterial colonization pattern with a deficiency of commensal bacteria may lead to a further breakdown of these host defense mechanisms, predisposing the infant to NEC. Here, we review the role of the innate and adaptive immune system in the pathophysiology of NEC. (C) 2016 Elsevier Inc. All rights reserved.
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