期刊
SEMINARS IN HEMATOLOGY
卷 54, 期 1, 页码 25-32出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.seminhematol.2016.10.001
关键词
Hematopoietic stem cells; Aging; Microenvironment; Cell-intrinsic; Cell-extrinsic
类别
资金
- National Institute of General Medical Sciences [K12 GM106997]
- National Institutes of Allergy and Infectious Diseases [U01 AI107276]
- National Cancer Institute [R01 CA166280]
- National Institute on Aging [R01 AG046293]
The hematopoietic system has the remarkable ability to provide a lifelong supply of mature cells that make up the entire blood and immune system. However, similar to other adult stem cell niches, the hematopoietic system is vulnerable to the detrimental effects of aging. This is a substantial health concern as the trend for population aging continues to increase. Identifying mechanisms that underlie hematopoietic aging is vital for understanding hematopoietic-related diseases. In this review, we first discuss the cellular hierarchy of the hematopoietic system and the components that make up the surrounding hematopoietic niche. We then provide an overview of the major phenotypes associated with hematopoietic aging and discuss recent research investigating cell-intrinsic and cell-extrinsic mechanisms of hematopoietic stem cell (HSCs) aging. We end by discussing the exciting new concept of possibly reversing the HSC aging process along with outstanding questions that remain to be answered. (C) 2017 Elsevier Inc. All rights reserved.
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