期刊
BIOMATERIALS
卷 112, 期 -, 页码 275-286出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.10.010
关键词
Click chemistry; Bioadhesives; Mussel; Citric acid; Antimicrobial
资金
- National Cancer Institute Award [CA182670]
- National Heart, Lung, and Blood Institute Award [HL118498]
For the first time, a convenient copper-catalyzed azide-alkyne cycloaddition (CuAAC, click chemistry) was successfully introduced into injectable citrate-based mussel-inspired bioadhesives (iCMBAs, iCs) to improve both cohesive and wet adhesive strengths and elongate the degradation time, providing numerous advantages in surgical applications. The major challenge in developing such adhesives was the mutual inhibition effect between the oxidant used for crosslinking catechol groups and the Cu(II) reductant used for CuAAC, which was successfully minimized by adding a biocompatible buffering agent typically used in cell culture, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), as a copper chelating agent. Among the investigated formulations, the highest adhesion strength achieved (223.11 +/- 15.94 kPa) was around 13 times higher than that of a commercially available fibrin glue (15.4 +/- 2.8 kPa). In addition, dual-crosslinked (i.e. click crosslinking and mussel-inspired crosslinking) iCMBAs still preserved considerable antibacterial and antifungal capabilities that are beneficial for the bioadhesives used as hemostatic adhesives or sealants for wound management. (C) 2016 Elsevier Ltd. All rights reserved.
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