期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 72, 期 -, 页码 10-18出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.11.010
关键词
Myogenic regulatory factors; MyoD; Skeletal muscle; Myogenesis
资金
- US National Institutes for Health [R01AR044031]
- E-Rare-2: Canadian Institutes of Health Research/Muscular Dystrophy Canada [ERA-132935]
- Muscular Dystrophy Association
- Stem Cell Network
- Canadian Institutes of Health Research [FDN-148387]
The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype. The application of genome-wide technologies has provided important new information as to how the MRFs function to activate muscle gene expression. Application of combined functional genomics technologies along with single cell lineage tracing strategies will allow a deeper understanding of the mechanisms mediating myogenic determination, cell differentiation and muscle regeneration. (C) 2017 The Authors. Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据