期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 71, 期 -, 页码 30-41出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.08.030
关键词
Cell membrane; Membrane tension; Cytoskeleton; Mechanobiology; Cell migration; Actin
资金
- IFOM (Istituto FIRC di Oncologia Molecolare, Milan, Italy)
- Brazilian agency Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Brazilian agency Fundacao de Amparo a Pesquisa do Rio de Janeiro (FAPERJ)
The plasma membrane separates the interior of cells from the outside environment. The membrane tension, defined as the force per unit length acting on a cross-section of membrane, regulates many vital biological processes. In this review, we summarize the first historical findings and the latest advances, showing membrane tension as an important physical parameter in cell biology. We also discuss how this parameter must be better integrated and we propose experimental approaches for key unanswered questions. (C) 2017 Elsevier Ltd. All rights reserved.
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